351306

IL7R antibody from BioLegend
CD127, IL7RA

Antibody data

Product number
351306
Provider
BioLegend
Proper citation
BioLegend Cat#351306, RRID:AB_10718639
Product name
Pacific Blue™ anti-human CD127 (IL-7Rá) [A019D5]
Provider product page
BioLegend - 351306
Antibody type
Monoclonal
Antigen
Recombinant human CD127
Description
CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Recent studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.
Reactivity
Human
Host
Mouse
Conjugate
Blue dye
Isotype
IgG
Vial size
100 tests
Storage
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.